Drug Discovery Services

Aurora is one of the best resource for scientists in the innovative drug design and early-stage drug development projects. Aurora's structure-based drug design, lead optimisation and predictive toxicology supports decision making in drug discovery in every company or organization regardless of its size. Aurora's approach has been to understand how the deseases are controlled at the molecular level and to target specific entities based on this knowledge.

Aurora's process of drug discovery involves the identification of candidates and their synthesis and characterization. Screening and assays for therapeutic efficacy could be provided in cooperation with our partners.

Drug design is another tool for drug discovery, whereby on the base of the target properties Aurora's software picks the specific small molecules from the company's own huge library of chemicals that might fit into an active zone of target. Absolutely new drugs and pharmacophores can emerge within several days from this drug design process.

The lead compounds with sufficient target potency, selectivity and favourable drug-like properties will then be proposed for further drug development.

See the following links where Aurora Fine Chemicals has related services that will benefit your projects:

• Virtual screening
  • Compound profiling prediction
  • Virtual High Throughput Screening

• Chemical and physiological properties prediction
  • Solubility in Water/DMSO prediction
  • LogP and LogD Calculation
    • Plasma protein binding - affinity constant for serum albumin
      pKa - the negative log to base 10 of the acid dissociation constant
      LogBB - blood-brain barrier permeation
      Lipinski's Rule of Five, an evaluation of druglikeness
  • Virtual Identification of a Protein Target

• Drug leads design
• ADME modeling
• Toxicity prediction
• Patentability check